Dicer rabbit polyclonal
|Protein full name||Endoribonuclease Dicer|
|DICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III|
|Immunogen||KLH conjugated Synthetic peptide corresponding to Mouse Dicer|
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation.
Immunohistochemistry analysis of paraffin-embedded rat brain using Dicer (GB11410) at dilution of 1:1000
Immunohistochemistry analysis of paraffin-embedded human kidney using Dicer (GB11410) at dilution of 1:1000
|Storage||Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.|
|Storage Buffer||PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.|
NOTE: This product is intended for research only.