|Description||2B4 rabbit polyclonal|
|Protein full name||Natural killer cell receptor 2B4|
|Synonyms||NK cell type I receptor protein 2B4, NKR2B4, Non-MHC restricted killing associated, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, 2b4, Nmrk|
|Immunogen||Recombinant protein corresponding to
|Predicted MW.||45 kDa|
|Observed MW.||60 kDa|
|Uniprot ID||Q9BZW8, Q07763, Q9JLM2|
|WB||Human, Mouse, Rat||1: 500-1: 1000||lung, lymph node, spleen, thymus|
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome.
Western blot analysis of 2B4 (GB111427)
|Storage||Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.|
|Storage Buffer||PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.|
NOTE: This product is intended for research only.