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Anti -GPR161 Rabbit pAb

货号:GB111421

品牌:Servicebio

价格:¥650

规格: 100 μl

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Product Information

 

Description GPR161 rabbit polyclonal
Protein full name G-protein coupled receptor 161
Synonyms Gpr161, Gm208, RE2, G protein coupled receptor RE2
Immunogen KLH conjugated Synthetic peptide
corresponding to Mouse GPR161
Isotype IgG
Purity Affinity purification
Predicted MW. 60 kDa
Observed MW. 65 kDa
Uniprot ID B2RPY5

 


 

Applications

 

Applications Species Dilution Positive Tissue
WB Mouse, Rat 1: 500-1: 1000 heart, brain

 


 

Background

 

GPR161 (also known as RE2) is an orphan G protein-coupled receptor and plays important roles in the Hh pathway. In the absence of Hh signals, GPR161 localizes to primary cilia and keeps the downstream GLI transcription factors in their repressor forms . Ciliary localization of GPR161 requires TULP3 and the IFT-A complex. In presence of SHH, GPR161 is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.

     


 

Images

 

Western blot analysis of GPR161 (GB111421) at dilution of 1: 1000
Lane 1: Mouse heart tissue lysate
Lane 2: Mouse brain tissue lysate
Lane 3: Rat heart tissue lysate
Lane 4: Rat brain tissue lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.