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Anti -Constitutive androstane receptor Rabbit pAb

货号:GB111418

品牌:Servicebio

价格:¥650

规格: 100 μl

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Product Information

 

Description Nr1i3 rabbit polyclonal
Protein full name Nuclear receptor subfamily 1 group I member 3
Synonyms Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, Nr1i3, Car, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3
Immunogen Recombinant protein corresponding to
Mouse Nr1i3
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus, Cytoplasm
Predicted MW. 41 kDa
Observed MW. 41 kDa
Uniprot ID O35627, Q9QUS1

 


 

Applications

 

Applications Species Dilution Positive Tissue
WB Mouse, Rat 1: 500-1: 1000 liver
IHC Mouse, Rat 1: 500-1: 1000 liver

 


 

Background

 

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs.

     


 

Images

 

 




Western blot analysis of Nr1i3 (GB111418)
at dilution of 1: 1000
Lane 1: Mouse liver tissue lysate
Lane 7: Rat liver tissue lysate





Immunohistochemistry analysis of paraffin-embedded mouse liver using
Nr1i3 (GB111418) at dilution of 1: 800

Immunohistochemistry analysis of paraffin-embedded rat liver using
Nr1i3 (GB111418) at dilution of 1: 500

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.