Product Information
| Description |
VEGFA rabbit polyclonal |
| Protein full name | Vascular endothelial growth factor A |
|
Synonyms |
VEGFA, MVCD1, VEGF, VPF, vascular endothelial growth factor A |
| Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse VEGFA |
| Isotype | IgG |
| Purity | Affinity purification |
|
Predicted MW. |
34-45 kDa |
|
Observed MW. |
34-45 kDa |
| Uniprot ID |
Applications
| Applications |
WB |
| Species |
Human, Mouse, Rat |
| Dilution |
1: 1000 |
| Positive tissue |
B16, liver cancer, kidney |
Background
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development .
Images
|
|
Western blot analysis of VEGFA (GB11034B) at dilution of 1: 1000. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
