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Anti -HIF-1 alpha Rabbit pAb

货号:GB111339

品牌:Servicebio

价格:¥650

规格: 100 μl

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Product Information

 

Description

HIF-1 alpha rabbit polyclonal

Protein full name Hypoxia-inducible factor 1-alpha
 

Synonyms

HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse HIF-1α

Isotype IgG
Purity Affinity purification

Predicted MW.

120 kDa

Observed MW.

120 kDa

Uniprot ID

Q16665

 


 

Applications

 

Applications

WB

Species

Human

Dilution

1: 500-1: 1000

Positive tissue

anaerobic Hela, anaerobic A549

 


 

Background

 

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
 


 

Images

 

Western blot analysis of HIF-1 alpha (111339) at dilution of 1: 1000.
Lane 1: Hela cell lysate (normoxia cultivation)
Lane 2: Hela cell lysate (anaerobic cultivation)
Lane 3: A549 cell lysate (normoxia cultivation)
Lane 4: A549 cell lysate (anaerobic cultivation)
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.