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Anti -AMACR Rabbit pAb

货号:GB111195

品牌:Servicebio

价格:¥500

规格: 100 μl

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Product Information

 

Description

AMACR rabbit polyclonal

Protein full name
Alpha-methylacyl-CoA racemase

Synonyms

2-methylacyl-CoA racemase, AMACR

Immunogen

KLH conjugated Synthetic peptide corresponding to Human AMACR

Isotype IgG
Purity Affinity purification
Subcellular location

Cytoplasm

Uniprot ID

Q9UHK6

 


 

Applications

 

Applications

IHC

Species

Human

Dilution

1: 1000-1: 2000

Positive tissue

ovary cancer, bladder cancer, prostate cancer

 


 

Background

 

AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).
 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded human ovary cancer using AMACR (GB111195) at dilution of 1: 2000
 

   

Immunohistochemistry analysis of paraffin-embedded human bladder cancer using AMACR (GB111195) at dilution of 1: 1200
 

   

Immunohistochemistry analysis of paraffin-embedded human prostate cancer using AMACR (GB111195) at dilution of 1: 2000
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.