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Anti -RAB7 Rabbit pAb

货号:GB111190

品牌:Servicebio

价格:¥500

规格: 100 μl

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Product Information

 

Description

RAB7 rabbit polyclonal

Protein full name
Ras-related protein Rab-7a

Synonyms

Rab7a, Rab7

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse RAB7

Isotype IgG
Purity Affinity purification

Predicted MW.

23 kDa

Observed MW.

23 kDa

Uniprot ID

P51149, P51150, P09527

 


 

Applications

 

Applications

WB

Species

Human, Mouse, Rat

Dilution

1: 500-1: 1000

Positive tissue

kidney, lung

 


 

Background

 

Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events.Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway .
 


 

Images

 

Western blot analysis of RAB7 (GB111190) at dilution of 1: 1000
Lane 1: HepG2 cell lysate
Lane 2: A431 cell lysate
Lane 3: Raw264.7 cell lysate
Lane 4: NIH/3T3 cell lysate
Lane 5: PC12 cell lysate
Lane 6: Mouse kidney tissue lysate
Lane 7: Mouse lung tissue lysate
Lane 8: Rat kidney tissue lysate
Lane 9: Rat lung tissue lysate
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.