Product Information
| Description |
MAML1 rabbit polyclonal |
| Protein full name |
Mastermind-like protein 1 |
|
Synonyms |
Mam-1, Maml1, Kiaa0200, Mastermind like 1 |
| Immunogen |
Recombinant protein corresponding to Mouse MAML1 |
| Isotype | IgG |
| Purity | Affinity purification |
|
Predicted MW. |
108 kDa |
|
Observed MW. |
130 kDa |
| Uniprot ID |
Applications
| Applications |
WB |
| Species |
Human, Mouse |
| Dilution |
1: 500-1: 1000 |
| Positive tissue |
lung, thymus |
Background
MAML1, also named as KIAA0200 and Mam-1 , belongs to the mastermind family. It acts as a transcriptional coactivator for NOTCH proteins. MAML1 has been shown to amplify NOTCH-induced transcription of HES1. It enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. MAML1 binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. It plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. The calculated molecular weight of MAML1 is 108 kDa, but modified MAML1 is about 120-130 kDa.
Images
|
|
Western blot analysis of MAML1 (GB111056) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
