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Anti -MAML1 Rabbit pAb

货号:GB111056

品牌:Servicebio

价格:¥650

规格: 100μl

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Product Information

 

Description

MAML1 rabbit polyclonal

Protein full name

Mastermind-like protein 1

Synonyms

Mam-1, Maml1, Kiaa0200, Mastermind like 1

Immunogen

Recombinant protein corresponding to Mouse MAML1

Isotype IgG
Purity Affinity purification

Predicted MW.

108 kDa

Observed MW.

130 kDa

Uniprot ID

Q92585, Q6T264

 


 

Applications

 

Applications

WB

Species

Human, Mouse

Dilution

1: 500-1: 1000

Positive tissue

lung, thymus

 


 

Background

 

MAML1, also named as KIAA0200 and Mam-1 , belongs to the mastermind family. It acts as a transcriptional coactivator for NOTCH proteins. MAML1 has been shown to amplify NOTCH-induced transcription of HES1. It enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. MAML1 binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. It plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. The calculated molecular weight of MAML1 is 108 kDa, but modified MAML1 is about 120-130 kDa.

 


 

Images

 

Western blot analysis of MAML1 (GB111056) at dilution of 1: 1000

Lane 1: Jurkat cell lysate
Lane 2: Hela cell lysate
Lane 3: HepG2 cell lysate
Lane 4: Mouse lung tissue lysate
Lane 5: Mouse thymus tissue lysate
Lane 6: Rat lung tissue lysate
Lane 7: Rat thymus tissue lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.