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Anti -cIAP2 Rabbit pAb

货号:GB111051

品牌:Servicebio

价格:500

规格: 100 μl

简介: Product Information Description cIAP2 rabbit polyclonal Protein full name Baculoviral IAP repeat-containing protein 3 Synonyms

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Product Information

 

Description

cIAP2 rabbit polyclonal

Protein full name

Baculoviral IAP repeat-containing protein 3

Synonyms

Cellular inhibitor of apoptosis 2, C-IAP2, Birc3, Inhibitor of apoptosis protein 1, mIAP1, RING-type E3 ubiquitin transferase BIRC3

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse cIAP2

Isotype IgG
Purity Affinity purification
Subcellular location

Nucleus, Cytoplasm

Predicted MW.

67 kDa

Observed MW.

67 kDa

Uniprot ID

O08863Q5XIW4

 


 

Applications

 

Applications

WB

IHC

IF

Species

Mouse, Rat

Mouse

Mouse

Dilution

1: 500-1: 1000

1: 1500-1: 3000

1: 750-1: 1500

Positive tissue

thymus, testes,lymph nodes 

lung, testis, spleen

lung, testis, spleen

 


 

Background

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. 

 


 

Images

 

image.png

Western blot analysis of cIAP2 (GB111051) at dilution of 1: 750

 

Lane 1: Mouse thymus tissue lysate

Lane 2: Mouse lymph nodes tissue lysate

Lane 3: Mouse testes tissue lysate

Lane 4: Rat thymus tissue lysate

   
image.png

Immunohistochemistry analysis of paraffin-embedded mouse lung using cIAP2 (GB111051) at dilution of 1: 3000

   
image.png

Immunohistochemistry analysis of paraffin-embedded mouse testis using cIAP2 (GB111051) at dilution of 1: 3000

   
image.png

Immunohistochemistry analysis of paraffin-embedded mouse spleen using cIAP2 (GB111051) at dilution of 1: 3000

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

 

NOTE: This product is intended for research only.